Clinical Trials

Inclusion Criteria:

• For all participants:

  • Individuals ages 12-17 years.

• Additional criteria for adolescents with obesity:

  • BMI ≥ 95^th percentile for age and gender based on CDC growth charts.

• Additional criteria for adolescents in control group:

  • BMI between the 25^th and 75^th percentile for age and gender based on CDC growth charts.

  • No prior diagnosis of obesity or obesity-related co-morbidities (such as type 2 diabetes, metabolic-associated steatotic liver disease)

Exclusion Criteria:

• Principal investigator discretion.

• Non-English-speaking caregivers and/or individuals.

• Individuals who are unable to sign consent or assent (e.g., those declared legally incompetent)

• Pregnancy

• Significant untreated psychiatric dysfunction including mood disorders, substance use disorders binge eating disorders and bulimia.

• Diabetes mellitus (type 1 or type 2)

• Current or prior use of anti-obesity medications (GLP-1 receptor agonists, phentermine, topiramate)

• History of bariatric surgery.

• Secondary causes of obesity such as syndromic/monogenic causes, hypothalamic obesity, Cushing’s syndrome.

• Ongoing use of any medications that can affect weight or appetite including stimulants, glucocorticoids, antipsychotics and antiseizure medications.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 7/23/2025. Questions regarding updates should be directed to the study team contact.