A Study Of Obesity Phenotyping And Response To Anti-Obesity Medications In Adolescents With Obesity

Overview

About this study

The purpose of this study is to determine if there is an association between obesity phenotype derived from genomic markers and the treatment response to anti-obesity medications in adolescents with obesity.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Patients previously or currently treated with an anti-obesity medication (age 12-17 at the start of the anti-obesity medication) at Mayo Clinic, Rochester between Jan 1, 2000 and August 31, 2025.
Pre-treatment BMI at or above the 95th percentile for age and gender.

Exclusion Criteria:

Non-English-speaking caregivers and/or individuals
Patients with diabetes mellitus (type 1 or type 2).
Patients with a secondary cause of obesity such as syndromic/monogenic causes, hypothalamic obesity or Cushing’s syndrome.
Patients started on medications that can affect weight including stimulants, glucocorticoids, antipsychotics, and anti-seizure medications during the study period.
Conditions that can affect weight such as untreated hyperthyroidism or hypothyroidism, untreated celiac disease, growth hormone deficiency.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 9/15/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Seema Kumar, M.D.	Open for enrollment	Contact information: Leslie Saba saba.leslie@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Seema Kumar, M.D.

Open for enrollment

Contact information:

Leslie Saba

saba.leslie@mayo.edu

More information

Publications

Publications are currently not available

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