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Tab Title Description
The aim of this study is to establish and actively follow a prospective cohort of individuals from pancreas cancer families to ascertain the development of pancreatic cancer and other cancer types in these families.
We will establish and maintain a prospective cohort of individuals who do not have pancreas cancer but are members of a kindred with two or more blood-related family members with pancreas cancer, or with at least one blood-related family member with pancreas cancer and one relative who carries a variant in a gene known to be associated with pancreatic cancer.
We will administer questionnaires to these individuals every two years to ascertain diagnosis of pancreas cancer and other cancer types in these subjects and their families.
We may request a onetime blood sample (up to 50cc) from these individuals in the future.
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
An individual who was previously enrolled in IRB # 1197-00, 354-06, 355-06, or 19-010791
Is age 18 years or older.
Has a valid United States mailing address.
Has at least two blood-related relatives who have had pancreas cancer or has a blood-relative with pancreatic cancer and that relative carries a known germline mutation in APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, TP53 or mutations in other genes known to be associated with pancreatic cancer.
Exclusion Criteria:
An individual who is a prison inmate.
An individual who is not compos mentis (of sound mind, memory, and understanding), and not able to give consent.
Has personal history of pancreas cancer.
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 3/4/2025. Questions regarding updates should be directed to the study team contact.
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
Mayo Clinic principal investigator
Samuel Antwi, Ph.D.
Closed-enrolling by invitation
Bridget Schmidt
5072663294
Contact Usschmidt.bridget2@mayo.edu