A Study Of Photon-counting Detector CT With Improved Spectral Resolution

Overview

About this study

The purpose of this study is to determine the changes in multi-energy CT image quality of a PCD-CT scanner with improved spectral resolution relative to the existing commercial PCD-CT scanner. We hypothesize that the innovation PCD-CT scanner with improved spectral resolution will yield multi-energy CT images with increased contrast-to-noise ratio, lower image noise, more accurate material quantification, or decreased artifacts relative to multi-energy CT images acquired using the current commercial detector and that radiologists will prefer images from the innovation PCD-CT scanner. Multi-energy CT images for a range of body regions and clinical applications will be evaluated.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult patients 18 to 99 years of age

  • Patients receiving a clinically indicated PCD-CT exam for one of the relevant body regions/clinical applications.

  • Patients who are able and willing to sign the informed consent.

Exclusion Criteria:

  • Minors less than 18 years old

  • Patient unable to provide written informed consent

  • For subjects who would require iodinated contrast material, a previous reaction to iodinated contrast media or an eGFR below 30 mL/min/1.73m2

  • Pregnancy

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 01/14/2026. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Cynthia McCollough, Ph.D.

Contact us for the latest status

More information

Publications

Publications are currently not available
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CLS-20598423

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