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A Study Of Obesity Phenotypes To Improve Outcomes After Transcatheter Aortic, Mitral, And Tricuspid Valve Interventions

Overview

About this study

The purpose of this study is to To evaluate clinical outcomes mortality, hospital readmissions, procedural complications) among obese patients undergoing Transcatheter Aortic Valve Replacement (TAVR) stratified by BMI.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age ≥18 years.

  • (Retrospective) Underwent TAVR, mitral or tricuspid TEER, TMVR or TTVR between 2015–2024.

  • (Prospective) Scheduled for TAVR, mitral or tricuspid TEER, TMVR or TTVR after June 30th

  • Documented obesity defined as either:

    • BMI ≥30, or

    • BMI ≥27 with one or more weight-related comorbidities (e.g., hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease)

      within 6 months of the procedure.

  • Able to consent and complete pre-procedural visit.

Exclusion Criteria:

  • Missing BMI data.

  • Unable or unwilling to consent (for prospective registry)

  • Pregnancy

  • Incarceration

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 5/29/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Kyla Lara-Breitinger, M.D., M.H.S.

Contact us for the latest status

More information

Publications

Publications are currently not available

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CLS-20598361

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