Effects Of Nocturnal Dronabinol Use On Obstructive Sleep Apnea Treatment And Physiological Outcomes

Overview

About this study

To identify whether Dronabinol impacts CPAP therapy adherence and residual AHI compared to those with CPAP alone. To determine whether combination of CPAP/Dronabinol results in higher subjective sleep quality compared to CPAP therapy.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

21 – 70 years of age
Biological male or female
AHI between 15 – 50 events/hour

Exclusion Criteria:

BMI > 35 kg/m²
Diagnosed psychiatric disorders
Hypotension
History of seizures
History of substance abuse or recreational drug use or positive urine drug screen
History of uncontrolled disease including:
- o   Cardiovascular
  o   Pulmonary
  o   Gastrointestinal
  o   Pancreatic
  o   Hepatic
  o   Renal
  o   Hematological
  o   Endocrine (including Type I Diabetes)
  o   Neurological
  Urological
Pregnant or breastfeeding
Use of certain antimicrobial, chemotherapeutic, anticoagulant, hypoglycemic, anti-inflammatory, psychotropic, and antihistamine drugs
Prescribed CYP2C9 and/or CYP3A4 inhibitors
Severe OSA that in the investigator’s judgment should only begin CPAP treatment
Prior upper airway surgery for snoring or OSA as an adult
Significant defect in nasal patency due to anatomical abnormality or uncontrolled rhinitis
Bariatric surgery within 2 years
Medically managed weight-loss program within 6 months
Noninvasive treatment for OSA within 1 month (self-report)
History of shift work or rotating shifts within 1 month
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 4/30/2026. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Virend Somers, M.D., Ph.D.	Open for enrollment	Contact information: Nicholas Wozniak 5072558794 wozniak.nicholas@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Virend Somers, M.D., Ph.D.

Open for enrollment

Contact information:

Nicholas Wozniak

5072558794

wozniak.nicholas@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials