Clinical Trials

Liver transplant cohort — Inclusion Criteria:

• Adult patients (≥18 years)

• Diagnosed with cirrhosis based on clinical, laboratory, and/or imaging findings.

• In the process of liver transplant evaluation

• Ability to obtain informed consent from the patient or legally authorized representative

Liver transplant cohort — Exclusion Criteria:

• Acute liver failure as the indication for transplant.

• Active malignancy other than transplant-relevant hepatobiliary/neuroendocrine malignancies permitted by the underlying transplant protocol

Healthy comparator cohort — Inclusion Criteria:

• Age ≥18 years, with aim to keep age distribution as close as feasible to that of transplant population

• 10 male and 10 female volunteers

• Body mass index 18.0–30.0 kg/m² at the study visit.

• Self-reported absence of known cirrhosis or chronic heart,kidney or uncontrolled thyroid or diabetes

• Ability to obtain informed consent

• FibroScan liver stiffness measurement (LSM) <8.0 kPa.

• FibroScan controlled attenuation parameter (CAP) <260 dB/m.

• Blood records or health data will not be accessed

Healthy comparator cohort — Exclusion Criteria:

• Known advanced chronic liver disease/cirrhosis by self-report.

• LSM ≥8.0 kPa on study FibroScan.

• CAP ≥260 dB/m on study FibroScan.

• Known heart failure.

• Known diabetes mellitus

• End-stage renal disease or on dialysis.

• Known uncontrolled thyroid disease.

• Acute illness, infection, hospitalization, or other clinically significant condition at the time of assessment that may materially alter resting energy expenditure.

• Pregnancy

• Current direct supervisory, reporting, performance-evaluation, or dependent employment relationship with the Principal Investigator or another member of the study team.

• Eligibility will be confirmed by participant self report. Routine medical records, employee health records, occupational health records, and personnel records will not be accessed for screening or eligibility determination

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/23/2026. Questions regarding updates should be directed to the study team contact.