Clinical Trials

Inclusion Criteria:

• 18 years of age or older at the time of consent.

• The patient is scheduled for a medical appointment in the GIM RST EHP\HLC.

• Women of child-bearing potential must agree to undergo a urine pregnancy screening per standard Radiology departmental protocol in place, to prevent imaging of pregnant patients.

  • A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria:

    • Has not undergone a hysterectomy or bilateral oophorectomy; or

    • Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months).

• Have the ability to provide informed consent.

• Have the ability to complete all aspects of this trial.

• Have no contraindicating comorbid health conditions that would interfere with study participation, as determined by the clinical investigators.

Exclusion Criteria: 

• Subject has had and been treated for cancer in the past 3 years (with the exception of non-melanoma skin cancer).

• Subjects may not be receiving any other investigational agents for the treatment of cancer under study for a longitudinal study.

• Uncontrolled intercurrent illness, including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that, in the opinion of the investigator, would limit compliance with study requirements.

• Female subjects must not be pregnant or nursing since pregnancy is a contraindication to the administration of gadolinium-based contrast agents.

• Any contraindication to MRI per the Radiology Department’s routine protocol, e.g., MRI-incompatible objects, including but not limited to medical devices (e.g., pacemakers, AICD, etc.) and other foreign bodies.

• Patients that require anesthesia for MRIs.

• Patients with uncontrollable claustrophobia, severe lower back pain, and uncontrollable tremors, to the point that it would render them unable to tolerate an MRI study.

• An unstable medical or mental health condition as determined by the physician investigator.

All subjects being seen in the Healthy Longevity Clinic that meet study criteria, regardless of sex or race, will be approached or invited to participate.

Non-English speakers will be enrolled in the study but will not be specifically targeted. The study staff will follow the IRB policy “Non-English-Speaking Prospective Subjects who are Not Specifically Targeted for the Research Project”, including using independent medical interpreters to provide an oral explanation and the Mayo Clinic IRB's written Short Form/Authorization to Use and Disclose Protected Health Information form, stating that the elements of informed consent have been presented orally and a witness.

 Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 8/21/2025. Questions regarding updates should be directed to the study team contact.