Clinical Trials

Inclusion Criteria:

• Documented diagnosis of ATTR amyloidosis with cardiomyopathy, classified as either hATTR amyloidosis with cardiomyopathy or wtATTR amyloidosis with cardiomyopathy; AND
• Had an inadequate response to or could not tolerate standard of care, in the opinion of the investigator.
• Is not eligible for on-label use of commercial patisiran in the opinion of the investigator.

Exclusion Criteria:

• New York Heart Association (NYHA) Class IV NYHA Class III AND ATTR amyloidosis disease Stage 3 (defined as both N-terminal prohormone B-type natriuretic peptide (NT-proBNP) > 3000 ng/L and estimated glomerular filtration rate [eGFR] < 45 ml/min/1.73 m^2). [Gillmore 2018].
• Current or future participation in another investigational device or drug study, scheduled to occur during this study, or has received an investigational agent or device within 30 days (or 5 half-lives of the investigational drug, whichever is longer) prior to dosing (Day 1). Patients who have previously participated in a gene therapy trial for hATTR amyloidosis.
• Patients currently enrolled in, eligible for inclusion in, or who have dropped out of an ongoing interventional (therapeutic) clinical trial related to ATTR amyloidosis.

Eligibility last updated 4/21/23. Questions regarding updates should be directed to the study team contact.