Clinical Trials

Inclusion Criteria:  

 Heart Failure Decompensated Patients:

• Patient being admitted to one of the Cardiology services with the diagnosis of decompensated HF

• Has been receiving treatment for <24 hours

 Heart Failure Stable Patients:

• Patients with known heart failure diagnosis, stable Rx for at least 1 month, with either HFPEF or HFREF.

• Similar age and gender mix as decompensated patients

 Age and Gender matched healthy subjects:

• No history of cardiac out pulmonary disease

• Generally active

 Any age, healthy subjects:

• No history of chronic cardiac or pulmonary disease

Exclusion Criteria:

For heart failure patients: 

• Physical limitations that preclude the use of a mouthpiece or mask. Inability to collect at least 10-15 minutes of respiratory data.

• Severe pulmonary diseases, such as COPD or Pulmonary Fibrosis without a diagnosis of heart failure.

• Complete dependence on supplemental oxygen or inability to come off oxygen for more than 10-15 minutes

 For healthy controls:

• Inability to breathe on a mouthpiece or mask for less than 10-15 minutes.

• Known history of cardiac of pulmonary related disease (e.g., valve dz, arrythmia, COPD, IPF, asthma)

• Current smoker

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 08/26/2025. Questions regarding updates should be directed to the study team contact.