Clinical Trials

Inclusion Criteria:

• Males and females 18-70 years who are able to comprehend instructions, follow study procedures and who willing to provide written, informed consent will be included.
• Overweight/Obese volunteers will have a BMI 29.0 – 37.0 kg/m2
• Female subjects are eligible if they meet the following criteria:
  • Are not pregnant or nursing.
  • All women of childbearing potential will have a negative urine pregnancy test at screening and a negative urine pregnancy test day of admission for inpatient study visit.
  • Post Menopausal will be defined as I

Exclusion Criteria:

• Individuals with a history of a disease process such as:
  • Ischemic heart disease
  • Atherosclerotic valvular disease
  • Persistent blood pressure greater than 160/95 despite antihypertensive medication
• Smokers
• Diagnosis Diabetes Mellitus
• Concomitant use of medications that can alter free fatty acid metabolism, including, but not limited to niacin, thiazolidinediones, beta-blockers, oral or injected corticosteroids or anabolic steroids.
• Allergy to lidocaine

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/19/2024. Questions regarding updates should be directed to the study team contact.