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AI-Augmented Imaging For Early Detection Of Pancreatic Cancer Acronym: AI-PACED

Overview

About this study

To evaluate the feasibility and potential clinical utility of serial AI-augmented computed tomography (CT) imaging and longitudinal blood biobanking in individuals with glycemically-defined new-onset diabetes (gNOD) and elevated pancreatic cancer risk (ENDPAC score ≥3), with the aim of determining whether this approach enables earlier detection of pancreatic ductal adenocarcinoma (PDA) relative to symptom-driven diagnosis

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age ≥50 and ≤85 years.

  • Glycemically-defined new-onset diabetes (gNOD) with onset ≤180 days preceding enrollment.

  • ENDPAC score ≥3, based on validated risk stratification models.

  • Provide written or remote informed consent.

Exclusion Criteria:

  • Prior diagnosis of pancreatic ductal adenocarcinoma (PDA)

  • Known hereditary cancer syndromes (e.g., BRCA1/2, Lynch syndrome, PeutzJeghers)

  • Prior history of pancreatic surgery.

  • Pancreatic cyst surveillance at time of registration.

  • Contraindications to contrast-enhanced CT imaging per standard clinical practice at time of registration.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/10/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Ajit Goenka, M.D.

Contact us for the latest status

Contact information:

Alyssa Johnson M.H.A.

(507) 422-9721

johnson.alyssa@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20595012

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