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A Study Of Depressive Symptoms In ADPKD

Overview

About this study

The purpose of this study is to assess the feasibility of REJUVENATE (DNT) or CC for short-term improvement of mood and quality of life (QoL) in ADPKD. Since mood disorders and pain may be chronic conditions which wax and wane over time, we have included an education or attention control arm to assess the effect of time/attention on these responses.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • include confirmed clinical diagnosis of ADPKD using Pei-Ravine criteria, age 18-70, Pre-End Stage Kidney Disease, with Stage 1-5 CKD (eGFR >10 ml/min/1.73m2, with no anticipated dialysis or transplant within 12 months), Clinical or self-diagnosis of depression, and English-language fluency.

Exclusion Criteria:

  • include suicidal ideation/unstable mental illness of any kind, lack of access/ability to use internet-based programs, eGFR <10 ml/min/1.73m2, anticipated dialysis or transplant within 6 months, prior chronic dialysis, prior organ (liver or kidney) transplant, age <18 or > 70, lack of English language fluency, or significant cognitive impairment (Mini Mental Status Exam (MMSE) < 21, see Appendix).

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 6/19/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Neera Dahl, M.D., Ph.D.

Contact us for the latest status

Contact information:

Ryan Helland CCRP

rsttemporesgroup@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20594556

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