Anemia (hemoglobin <8.5 g/dL)
Body weight >150 kg or BMI >50
Uncontrolled hypertension: sustained systolic blood pressure (SBP) >160 mmHg or diastolic blood pressure (DBP) ≥100 mmHg despite maximal doses of at least 2 different classes of anti-hypertensive medications
Chronic hypotension history: sustained SBP <85 mmHg
Kidney failure requiring ongoing kidney replacement therapy (hemodialysis, peritoneal dialysis, or kidney transplantation)
Active immunosuppression therapy (including prednisone ≥10 mg daily)
Kidney transplantation history
Solid organ transplantation history
Recent cardiovascular event (hospitalization for myocardial infarction, stroke, congestive heart failure (NYHA class ≥III or ejection fraction ≤30%) within 3 months or uncontrolled cardiac arrhythmias (e.g. ventricular arrhythmia, supraventricular tachycardia and bradyarrhythmia)
History of liver cirrhosis
Chronic obstructive pulmonary disease or asthma requiring daily medication
History of recurring blood clotting disorder (thromboembolism; pulmonary embolism, deep venous thrombosis) requiring chronic anticoagulation therapy
Pregnancy
Unwilling to use contraception for at least 2 months after MSC infusion if sexually active and able to become pregnant or father a child.
Active malignancy
Active infection (e.g. systemic or specific organ involvement such as pneumonia or osteomyelitis)
Recent COVID-19 infection within the last 1 month
History of hepatitis B or C (without cure), or HIV infection
History of allergic reaction to cellular products (i.e. blood transfusions, platelets)
Active tobacco use
Illicit drug use and excessive alcohol use
Presence of psychosocial issues (e.g., uncontrolled mental illness, unpredictable childcare or eldercare responsibilities, irregular/ inflexible work schedule) that may interfere with the ability to complete all study procedures
Patients anticipating prolonged travel or other physical restrictions that would prohibit return for scheduled study visits.
Inability to give informed consent