A Study of Prehabilitation in Patients with Multiple Myeloma Receiving CAR-T Therapy

Overview

About this study

The purpose of this study is to evaluate the feasibility and acceptability of a 6-week home-based virtual prehabilitation program with remote monitoring in 20 patients ≥60 years with relapsed/refractory (R/R) multiple myeloma (MM) scheduled to receive CAR-T therapy at Mayo Clinic – Rochester.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Multiple Myeloma diagnosis
  • Females and males ≥60 years of age
  • ECOG score of <3
  • Scheduled for a CAR T Therapy transfusion
  • Apheresis date at least 7 days prior to date of enrollment
  • Primary hematologist attending physician clearance for exercise

Exclusion Criteria: 

  • Females or males <60 years of age
  • Any hematological cancer other than multiple myeloma
  • Evidence of an absolute contraindication (eg, heart insufficiency >NYHA III or uncertain arrhythmia; uncontrolled hypertension; reduced standing or walking ability for exercise).
  • Other comorbidities that preclude participation in the exercise as deemed by physical therapist or PM&R physician.
  • Active infections, active bleeding disorders, and cytopenias at risk for further adverse events deemed by hematologist-oncologist

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 02/25/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Nadine Abdallah, M.D.

Open for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information

Publications

Publications are currently not available
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CLS-20588048

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