A Study of Aging Mechanisms in Postoperative Delirium

Overview

About this study

The purpsoe of this study is to identify proteins that can be measured in blood and indicate that a patient is at high risk of delirium.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria (Patient):

70 years of age or older
Planned to undergo major elective surgery to include, lumbar, cervical, or sacral laminectomy; aortic abdominal aneurysm repair, lower extremity amputation, open or laparoscopic colectomy; as identified by appropriate ICD-10 procedure codes
Estimated length of stay >48 hours in hospital

Exclusion Criteria (patient):

Patient lacks capacity to consent and does not have LAR
Unable to communicate or participate in the study due to language barriers or sensory deficits
Prisoners
Upon enrollment moderate or severe dementia is indicated with Kokmen <20 or FAST scale >4
Patient admitted to hospice service or actively dying
History of delirium
Patients receiving blood transfusion during surgery will be excluded from day 1 and 3 blood draws

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 12/26/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Allyson Palmer, M.D., Ph.D.	Open for enrollment	Contact information: Donna Lawson CCRP (507) 255-7975 Lawson.Donna3@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Allyson Palmer, M.D., Ph.D.

Open for enrollment

Contact information:

Donna Lawson CCRP

(507) 255-7975

Lawson.Donna3@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials