Nailfold Video Capillaroscopy Testing with Esophageal Dysmotility in Patients with Systemic Sclerosis

Overview

About this study

The purpose of this study is to assess findings on nailfold video capillaroscopy (NVC) and their association with esophageal dysfunction, specifically esophageal symptoms through self- reported questionnaires and dysmotility assessed by high-resolution manometry (HRM) in patients with concern for systemic sclerosis, which may provide prognostic or diagnostic information using a noninvasive quick and safe procedure.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Patients
18 years and older, with normal or abnormal esophageal function testing on HRM.
Testing will be guided by discretion of Gastroenterologist/Rheumatologist or other specialties ordered as standard of care.

Exclusion Criteria:

Age less than 18 years of age.
Dialysis dependent.
Type 2 diabetes, recent hand trauma or manicure (<2 weeks), routine use of vibratory tools.
History of acrocyanosis or erythromelalgia.
Previous diagnosis of a bleeding disorder.
Diagnosis of psoriasis.
Diagnosis of anti-phospholipid syndrome.
Exposure to toluene or benzoyl.
Diagnosis of psoriasis.
Diagnosis of COPD.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 2/07/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Jacksonville, Fla. Mayo Clinic principal investigator Andree Koop, M.D.	Closed-enrolling by invitation What is this? (?) "Close" Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.	Contact information: Wendi Lehman Lehman.Wendi@mayo.edu

Mayo Clinic Location

Status

Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Andree Koop, M.D.

Closed-enrolling by invitation

Contact information:

Wendi Lehman

Lehman.Wendi@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials