Clinical Trials

Inclusion Criteria – Postmenopausal women (Post-MP):

• Healthy postmenopausal women with 40-70 years
• After 6 months of natural menopause.

Inclusion Criteria – MAC infected Postmenopausal women (MAC+ Post-MP):

• Postmenopausal 40-70 years .
• Patient must be infected or have history of Mycobacterium avium complex lung disease (MAC-LD)
• MAC-LD diagnosed by as per current ATS/IDSA guidelines (Clinical, radiographic and microbiological evidence).

Inclusion Criteria – pre-menopausal women (Pre-MP):

• Healthy pre-menopausal (40-50 years) women.

Inclusion Criteria – Males:

• Healthy males aged 41-50 and 60-70-years

Exclusion Criteria:

• Individuals under 40 years of age
• Subjects who are on sex hormonal treatment and/or use of hormonal contraceptives,
• Current breastfeeding, pregnancy, and women who gave birth in the last six months.
• History of HIV infection, and patients on immunosuppressive drugs therapy.
• Patients receiving anti-MAC antibiotics in the last 90 days
• History of MAC-LD or suspected MAC-LD radiologically for healthy study volunteers.
• Patients with history of treatment failure for study patients with history of MAC-LD.
• Co-infection of non-tuberculous mycobacterial species other than MAC.
• Recent diagnosis of COVID-19.
• Subjects are unable to give written informed consent

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 09/24/2024. Questions regarding updates should be directed to the study team contact.