Clinical Trials

Inclusion Criteria:

* Ability to read, write, and understand English
* Minimum DAST (1+), audit-C score (3+)
* Access and willingness to use a mobile device for asynchronous (text) and synchronous (video) engagement with care.
* Access to or willingness to obtain a Primary care provider at a participating Mayo Clinic site;
* Eligibility determined by ASAM Assessment

Exclusion Criteria:

* Diagnosed personality pathology as the primary presenting concern based on clinical judgment, severe cognitive impairment (e.g., intellectual disability or dementia), or psychosis
* Inability to actively participate in and learn from psychotherapeutic interaction based on clinical evaluation and clinical judgment
* Needing a higher level of mental health care as demonstrated by ASAM32 assessment.
* Decline to answer suicidality questions.
* Already admitted into or about to initiate treatment in another addiction treatment program.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/28/2025. Questions regarding updates should be directed to the study team contact.