Imaging Studies In Corticobasal Syndrome

Overview

About this study

The primary goal of this study is to investigate inflammation and white matter damage in corticobasal syndrome and determine whether these processes are related to each other. The investigator's will address our goal by using neuroimaging and blood plasma biomarkers, as well as molecular pathology.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

* Age 18 years or older
* Meet possible or probable CBS criteria

Exclusion Criteria:

* Subjects will be excluded if MRI is contraindicated (due to implanted device, severe claustrophobia, etc)
* Subjects will be excluded if they have a concurrent illnesses or structural abnormality that could account for the CBS syndrome
* Subjects will be excluded if they have a mutation in the progranulin gene
* Subjects will excluded if they have received anti-Aβ therapy
* Women who are pregnant will be excluded
* Subjects will be excluded if they are actively taking daily anti-inflammatory medications (NSAIDs, corticosteriods, etc)
* Subjects will be excluded if they have generalized inflammatory condition and treatment with immunosuppressive, corticoid/glucocorticoid, steroidal or non-steroidal anti-inflammatory medication within 2 weeks of scanning

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 9/25/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Jennifer Whitwell, Ph.D.	Open for enrollment	Contact information: Sarah Boland CCRP (507) 284-3863 Boland.Sarah@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jennifer Whitwell, Ph.D.

Open for enrollment

Contact information:

Sarah Boland CCRP

(507) 284-3863

Boland.Sarah@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials