Clinical Trials

Inclusion Criteria:

• All subjects enrolled must be over the age of 18.
• Subjects must meet possible or probable CBS criteria; hence, patients must have at least one motor sign (limb rigidity/akinesia, limb dystonia, or limb myoclonus), plus one cortical sign (orobuccal/limb apraxia, cortical sensory deficit, or alien limb phenomena).
• Subjects meeting criteria for CBS, but having additional symptoms, including memory loss, will be included.

Exclusion Criteria:

• Subjects will be excluded if MRI is contraindicated (due to implanted device, severe claustrophobia, etc).
• Subjects will be excluded if they have a concurrent illnesses or structural abnormality that could account for the CBS syndrome, if they have a mutation in the progranulin gene or received anti-Aβ therapy.
• All women who can become pregnant must have a negative pregnancy test before the PET/CT scans.

Additional exclusion criteria for the C-11 ER176 PET scan:

• Actively taking daily anti-inflammatory medications (NSAIDs, corticosteriods, etc) except for a small control group.
• Anti-inflammatory creams, eye drops and nasal sprays are not exclusions.Generalized inflammatory condition and treatment with immunosuppressive, corticoid/glucocorticoid, steroidal or non-steroidal anti-inflammatory medication within 2 weeks of scanning

• Subjects will be asked to pause daily anti-inflammatory medications for two weeks prior to the ER176 PET scan. If they are not able to pause treatment, subjects will still be included in the study as they can help us meet other aims of the grant.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 07/24/2024. Questions regarding updates should be directed to the study team contact.