Graded Exercise Hypoxia Testing

Overview

About this study

The purpose of this study is to develop a single, standardized test to determine how individuals tolerate acute hypoxia in a stepwise fashion. We aim to evaluate the association between multiple factors, such as ventilatory compensation, heart rate response, acid-base changes, sex, pulmonary function, etc, which may explain why some individuals tolerate exercise in hypoxia better than others. Identifying these factors of association will inform future pharmacological and non-pharmacological attempts to combat acute hypoxic exercise.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Age ≥ 18 years

Exclusion Criteria:

Contraindications to exercise testing
Currently pregnant
Musculoskeletal or metabolic disease
Allergies to lidocaine
Body-mass index ≤ 18 or ≥3 5 kg·m-2
Pacemaker
No confounding cardiorespiratory disease
Persistent tobacco use (> 15 pack years)

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 1/22/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Michael Joyner, M.D.	Open for enrollment	Contact information: Nancy Meyer (507) 255-0913 Meyer.Nancy2@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Open for enrollment

Contact information:

Nancy Meyer

(507) 255-0913

Meyer.Nancy2@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials