Clinical Trials

AIM 1: To externally validate our machine learning model to differentiate aspirators from non-aspirators.

Inclusion Criteria:

• Any patient at or above 18 years of age who has voice recordings available in clinical databases. These include voices recorded in clinics, during routine laryngoscopies, voice/swallow assessments etc. Additionaly those who have VFSS and/or FEES imaging available will be included.

• Adults aged 18-100.

Exclusion Criteria:

• Patient’s below 18 years of age, vulnerable population (Pregnant women, prisoners and institutionalized), patients with tracheostomies and those who have expressly declined authorization for research at the Mayo Clinic enterprise.

AIM 2: To develop a ML model that can analyze voice to predict Forced Expiratory Volume in the 1st second (FEV1), using in laboratory spirometry as the gold standard. (Prospective Observational)

AIM 3: To develop a ML model that can analyze voice to predict the degree of frailty, using the modified Fried Frailty Phenotype (FFP) assessment as the gold standard. (Prospective Observational)

• Adults aged 18-100.

Inclusion Criteria:

• Any patient at or above 18 years of age who are to undergo in lab PFT measurement or in facility frailty assessment at MCA, but sepcifically in the pulmonary rehabilitation area at MCA Pulmonary department. Depending on success at MCA this will likely be expanded to other Mayo sites.

Exclusion Criteria:

• Same as in AIM 1.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 4/4/2024. Questions regarding updates should be directed to the study team contact.