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High-Resolution Esophageal Manometry to Establish Pressures at the Esophagogastric Junction During Diaphragmatic Breathing

Overview

About this study

The purpose of this study is to determine which position, maneuvers, commands, or combination thereof generates the highest pressure at the EGJ as assessed by high-resolution esophageal manometry and thus greater or more robust contraction of the diaphragm.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adults, age ≥ 18, men and women.
  • Undergoing esophageal manometry.

Exclusion Criteria: 

  • Prior esophageal or gastric surgery.
  • Prior diagnosis of achalasia.
  • Chest tube.
  • Major concomitant illness.
  • Sinus disease precluding manometry placement.
  • History of heavy alcohol or tobacco use.
  • Poor comprehension and/or fluency of English language.
  • Inability or unwillingness of individual to give written informed consent.

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 12/6/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Andree Koop, M.D.

Open for enrollment

Contact information:

Wendi Lehman

(904) 953-8742

Lehman.Wendi@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20564811

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