The Effects of Acute and Chronic Exercise on the Immune Phenotype of Chronic Lymphocytic Leukemia Patients


About this study

The purpose of this study is to determine how circulating immune cell abundance and function (via cell counts & cytokine profile) of individuals with indolent non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL ) respond to acute (single bout) maximal exercise and how this differs from the response observed in group of age-matched controls by monitoring cardiopulmonary parameters and mobilization of immune cell phenotypes. Additionally this study will also evaluate the effectiveness of 12-weeks of semi-supervised exercise training (ET) vs. usual care (UC) at improving quality of life (QOL) and physical fitness, modulating the circulating immune cell mobilization and immune function in response to acute exercise in individuals with indolent NHL during or after treatment compared to UC.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • 18-80 years of age will participate in this study
  • Diagnosis of CLL/SLL (chronic lymphocytic leukemia/small lymphocytic lymphoma) will be required to participate in Aim 2 of this study.

Exclusion Criteria:

  • Healthy subjects participating in Aim 1 will be excluded if they have known cardiovascular or pulmonary disease (e.g., heart disease, coronary artery disease, chronic obstructive pulmonary disease [COPD], asthma, etc.) an orthopedic or musculoskeletal limitation which would limit ability to exercise or are a current or former smoker.

Eligibility last updated 5/30/2023. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Neil Kay, M.D.

Open for enrollment

Contact information:

Courtney Wheatley-Guy Ph.D.

(480) 301-6616

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Michael Gustafson, Ph.D.

Open for enrollment

Contact information:

Jordan Parks

(480) 301-6616

More information


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