Umbilical Cord MSC's


About this study

The objectives of this study are to determine the effect of Human Umbilical Cord MSCs Derived Exosome / Extracellular Vesicle (uEV) on adult neural stem cells (NSCs) in-vito, and to assess the functional benefit of human uEV treatment on rats with spinal cord injury.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Healthy, full-term women (18-35 years old) who underwent elective cesarean section.
  • Free of Human Immunodeficiency Virus (HIV) types 1 & 2, Hepatitis A, B, and C, Treponema pallidum, Chlamydia trachomatis, Neisseria gonorrhea, and HTLV 1 & 2.
  • Able to give written informed consent prior to collection of the cord.

Exclusion Criteria: 

  • On chronic, immunosuppressive transplant therapy or having a chronic, immuno-suppressive state, including use of systemic steroids/corticosteroids.
  • Takin anti-rheumatic disease medication (including methotrexate or other antimetabolites) within 3 months prior to study enrollment.
  • Ongoing infectious disease, including but not limited to tuberculosis, HIV, Hepatitis, and syphilis.
  • History of malignancy including melanoma except for localized skin cancers (with no evidence of metastasis, significant invasion, or re-occurrence within three years of baseline). Any other malignancy will not be allowed.

Eligibility last updated 12/16/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Mohamad Bydon, M.D.

Open for enrollment

Contact information:

Osha Grant

(507) 293-7992

More information


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