Diagnosis of Native Vertebral Osteomyelitis by Assessing the Utility of Disc Space Aspirate Cell Count and Differential


About this study

The purpose of this study is to validate the utility of disc space aspirate cell count and differential in the diagnosis of NVO in a large patient cohort, and propose an updated algorithm for the workup of Native Vertebral Osteomyelitis (NVO) based on disc space aspirate cell count and differential


Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients 18 years of age or older.
  • Referred to the neuroradiology department for diagnostic image guided biopsy.
  • The reason for image-guided biopsy would either be due to suspicion for NVO or for other reasons such as ruling out malignancy.

Exclusion Criteria:

  • Patients less than 18 years of age.
  • Patients with spinal hardware / instrumentation.
  • Post operative patients.
  • Patients unable to provide consent.

Eligibility last updated 6/1/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Elie Berbari, M.D.

Open for enrollment

Contact information:

Said El Zein M.D.


More information


Publications are currently not available

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