A.I. Software Evaluation and Development for Breast Cancer Detection in Tomosynthesis Scans


About this study

The goal of this project is to develop an AI system for early cancer detection on routine screening tomosynthesis mammograms. There will be significant impact on clinical practices if a mammography AI tool can be built. Such a tool will improve efficiency and decrease false positives and false negatives in practice. 

This protocol captures the details for the reader study involving Aidoc, ScreenPoint, and iCAD. Mayo Clinic Breast Imaging Radiologists will evaluate the software tools that both ScreenPoint  and iCAD have developed for assisting in reading tomosynthesis scans. Aidoc is facilitating this study by providing their user interface tools. The radiologist will interface with the software where they will provide information for each subject. We will obtain the data through the system.  

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patient: who have had a screening mammogram performed at Mayo Clinic and had a biopsy confirmed cancer.
  • Physicians: members of Mayo Clinic’s staff.  Physician participants must agree to the consent statement verbally or via email.

Exclusion Criteria: 

  • For the enrichment cohort, women without biopsy confirmed cancer will be excluded.  
  • For the consecutive cases, male, children (less than 18 age), technically inadequate exam will be excluded.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Timothy Kline, Ph.D.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Timothy Kline Ph.D.

(507) 255-4199


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