A Study to Evaluate 4DCT Controls


About this study

The purpose of this study is to assess healthy controls without any history of wrist injury or diseases by using 4DCT scanning during wrist movement to characterize gapping at the scapholunate, radiolunate, and radioscaphoid joints, as well as the scaphotrapeziotrapezoid (STT) joint.  This will test the hypotheses that scapholunate and STT gapping distances and bilateral asymmetry will be greater in the resisted tasks as compared to the unresisted tasks in both male and female subjects, and that gapping in females will be greater than in males.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criterion:

  • Age ≥ 18 and ≤ 60 years.
  • Control subjects without any history of wrist injury or disease.

Exclusion Criteria (applied to both wrists for control subjects): 

  • Previously-diagnosed rheumatological conditions or connective tissue diseases.
  • Inability to be appropriately positioned in the scanner for the imaging.
  • Congenital malformations of the wrist or forearm.
  • Diagnosed wrist osteoarthritis.
  • Age under 18 or over 60.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Kristin Zhao, Ph.D., M.S.

Open for enrollment

Contact information:

Julie Block

(507) 538-4950


More information


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