Microbiome Study


About this study

 The aggregate of microorganisms inhabiting the human gastrointestinal tract is dynamic in nature. They change their composition secondary to various physiological and pathological insults including an intermittent hypoxic state in Obstructive sleep apnea. The overall hypothesis of this study is that the human gut microbial species diversity, its relative composition, and the substance produced by them in participants with obstructive sleep apnea are subject to change following continuous positive airway pressure therapy.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age between 18 to 70 years.
  • Able to provide consent.
  • Newly diagnosed with obstructive sleep apnea(OSA).

Exclusion Criteria: 

  • Apnea-Hypopnea Index < 15 (Mild obstructive sleep apnea).
  • Pregnant women.
  • Recent(< 4 weeks) use of antibiotic or probiotic.
  • Suffering from chronic or acute severe disease.

Eligibility last updated 8/18/21. Questions regarding updates should be directed to the study team contact.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Joseph Cheung, M.D.

Open for enrollment

Contact information:

Joseph Cheung M.D.

(904) 953-6413


More information


Publications are currently not available

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