The Role Of Interferon-gamma In Invasive Candidiasis


About this study

The purpose of this study is to evaluate the immune status of patients with Candida infection, particularly those that have infection that is difficult to treat. The study will also assess the role of interferon-gamma (a substance secreted by cells of the immune system).



Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Willing and able to provide written informed consent. If the subject is unable to consent for himself/herself, a legally authorized representative must provide informed consent on his/her behalf.
  • Males or females ≥ 18 years of age.
  • Evidence of candidemia or invasive candidiasis based on growth of Candida species from any of the following: blood, peritoneal fluid, intra-abdominal collection/abscess, pancreatic fluid/tissue, peripancreatic fluid, pleural fluid/tissue.

Exclusion Criteria:

  • Severe neutropenia (absolute neutrophil count < 500 cells/microL).
  • Profound lymphopenia (< 300 cells/microL).
  • The Principal Investigator (PI) is of the opinion that the subject should not participate in the study.

Eligibility last updated 8/23/21. Questions regarding updates should be directed to the study team contact.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Paschalis Vergidis, M.D.

Open for enrollment

Contact information:

Paschalis Vergidis M.D.

More information


Publications are currently not available

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