Iron-Immune System Interaction Shapes Renal Allograft Outcomes After Infections


About this study

The objectives of this study are to establish the dynamic changes in iron metabolism and circulating iron-regulatory immune cells in kidney transplant infection, and to determine quantitative changes in tissue levels of hepcidin and iron-regulatory macrophages in transplant biopsy and compare pyelonephritis case with control.


Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult kidney transplant recipients, 10 with pyelonephritis and 10 with no graft infection or rejection.

Exclusion Criteria:

  • Dual organ transplant.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Sundararaman Swaminathan, M.B.B.S., M.D.

Open for enrollment

Contact information:

Sonia Robertson

(480) 342-6677

More information


Publications are currently not available

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