The Role of Genetics and Socioeconomic Factors in Outcomes After Kidney Transplantation in Hispanics and American Indians

Overview

About this study

The objectives of this study are to retrospectively assess detailed post-transplant outcomes in a large cohort of patients across 3 sites with a specific emphasis on the outcomes of Hispanics and American Indians compared to non-white Hispanics, to develop and implement a questionnaire to assess socioeconomic risk factors in transplant patients (including a cohort of Hispanics and American Indians), and to perform genetic studies (high-resolution HLA typing and whole genome sequencing studies) to identify genes associated with transplant outcomes (diabetes, rejection and graft loss) in Hispanics and American Indians.  

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Hispanics, American Indians, and African Americans.
  • 25 Patients with a functioning graft at 5 years and 25 who had death-censored graft loss.
  • Differences in groups across the whole genome will be evaluated using ANOVA with p-value correction based on false discovery rate (FDR) using the PLINK software.

Exclusion Criteria:

  • None.

Eligibility last updated 11/30/21. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Mark Stegall, M.D.

Contact us for the latest status

Contact information:

Lauren Burnside

(507) 422-6061

Burnside.Lauren@mayo.edu

Jacksonville, Fla.

Mayo Clinic principal investigator

Hani Wadei, M.D.

Contact us for the latest status

Contact information:

Joel Espinoza B.S.

(904) 953-8855

Espinoza.Joel@mayo.edu

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Girish Mour, M.B.B.S., M.D.

Open for enrollment

Contact information:

Julieta Williams

(480) 342-1785

Williams.Julieta@mayo.edu

More information

Publications

Publications are currently not available
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CLS-20524214

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