Clinical Trials

Inclusion Criteria:

• Age, 18-45 years old.
• Ability to sign informed consent form.
• Body mass index (BMI), 18.0 – 26.0 kg/m^2 (lean subjects).
• Body mass index (BMI), 32.0-50.0 kg/m^2 (subjects with obesity).

Exclusion Criteria:

• Evidence of diabetes.
• Presence of acute illness.
• History of liver disease.
• Uncontrolled metabolic disease, including renal disease.
• Heart disease related to atrial fibrillation, history of syncope, limiting or unstable angina, congestive heart failure or ECG documented abnormalities such as > 0.2 mV horizontal or downsloping ST-segment depression, or frequent arrhythmias (> 10 premature ventricular contractions/min).
• Low hemoglobin or hematocrit.
• Use of anabolic steroids or corticosteroids (within 3 months).
• Not classified as inactive/sedentary based on accelerometry/ActivPal data (i.e., physical activity > 1.7 METs). 
• Current participation in a weight-loss regimen.
• Extreme dietary practices (i.e., vegan, vegetarian).
• Smoking (including electronic cigarettes and marijuana) subjects will be included as long as they are willing to abstain for 5 days prior to screening and infusion studies.
• Ppregnancy - women trying to become pregnant will be excluded from the study; women of child-bearingpotential will be able to participate in this study only if they have a negative pregnancy test and agree to use acceptable birth control during the course of the study [surgical sterilization, approved hormonal contraceptives (such as birth control pills, Depo-Provera), barrier methods (such as a condom or diaphragm) used with a spermicide, an intrauterine device (IUD), abstinence].
• Gastro-intestinal surgery.
• Any medication, intake of supplements, other condition, or event considered exclusionary by the PI and the study physician.

Eligibility last updated 1/24/22. Questions regarding updates should be directed to the study team contact.