A Study to Evaluate Interferon-gamma in Antifungal Immunity


About this study

The purpose of this study is to evaluate the role of interferon-gamma (IFN-γ) in antifungal defense and its potential use in adjunctive immunotherapy.  Solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients are at increased risk for invasive fungal infections.  Mortality rates remain unacceptably high despite antifungal treatment. Novel therapeutic modalities are urgently needed. In this project, we propose to study the role of interferon-gamma (IFN-gamma) in antifungal defense and its potential use in adjunctive immunotherapy. 



Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Subjects must meet the following inclusion criteria to qualify for the study:

  • Willing and able to provide written informed consent. If the subject is unable to consent for himself/herself, a legally authorized representative must provide informed consent on his/her behalf.
  • Males or females ≥18 years of age.
  • Have received solid organ transplant or allogeneic hematopoietic stem cell transplant at any time or have another immunocompromising condition.

Exclusion Criteria

Subjects must NOT meet any of the following exclusion criteria to qualify for the study:

  • Severe neutropenia (absolute neutrophil count <500 cells/microL).
  • Profound lymphopenia (<300 cells/microL).
  • The Principal Investigator (PI) is of the opinion the subject should not participate in the study.
  • Females who are pregnant.

Eligibility last updated 11/3/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Paschalis Vergidis, M.D.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Paschalis Vergidis M.D.


More information


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