Comparison of Hepatic Intraarterial vs. Systemic Intravenous 68Ga-PSMA PET/CT to Treat Hepatocellular Carcinoma

Overview

About this study

To determine the tumor radiotracer uptake of direct hepatic intraarterial (I.A.) versus systemic intravenous (I.V.) 68Ga-PSMA in patients with PSMA+ HCC by PET/CT. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients with either an imaging diagnosis of HCC by CT or MRI (LI-RADS 5) confirmed by a board-certified abdominal radiologist, or with biopsy-proven HCC.
  • Already enrolled in ongoing Transform the Practice or Department of Defense 68Ga-PSMA studies.
  • PSMA avid HCC detected by 68Ga-PSMA PET/CT after intravenous administration of 68Ga-PSMA confirmed by a board certified nuclear radiologist.
  • Undergoing planned hepatic artery embolization (HAE) per standard clinical care.
  • Male or female with age greater than 18 years, with the capacity and willingness to provide a written informed consent.

Exclusion Criteria:

  • Subjects requiring emergent surgery for a ruptured/bleeding HCC.
  • Pregnant and/or breast-feeding subjects. A negative pregnancy test within 48 hours of the PET scan.
  • Subjects with higher than the weight/size limitations of PET/CT scanner.

Eligibility last updated 10/8/21. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Scott Thompson, M.D., Ph.D.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Scott Thompson M.D., Ph.D.

(507) 284-2644

Thompson.Scott@mayo.edu

More information

Publications

Publications are currently not available
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CLS-20522737

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