Recovery of Respiratory System in COVID-19 Patients


About this study

This study aims to determine the effect of lingering COVID-19 symptoms on alveolar-capillary membrane conductance, pulmonary blood flow, exhaled nitric oxide, maximal respiratory pressures, lung clearance index and pulmonary function (flow rates, lung volumes, resistance, and reactance) and to examine the relationships between the respiratory physiology and exercise gas exchange between subjects with and without ongoing COVID-19 symptoms.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Have a documented positive qRT-PCR for SARS-CoV-2 confirming prior COVID-19 diagnosis within the last 2-3 months.
  • At least 18 years of age.
  • Female subjects must not be pregnant or trying to become pregnant during the duration of study participation.
  • No known plans to move out of the state, or become unable to return to one of the Mayo Clinic sites for follow-up testing.
  • Must be able to provide clear informed written consent.

Exclusion Criteria:

  • Individuals with pacemakers or other implantable devices that will make interpreting a CT scan challenging.
  • Individuals with major limitations to exercise.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Open for enrollment

Contact information:

Briana Ziegler

(507) 255-7125

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Courtney Wheatley-Guy, Ph.D.

Open for enrollment

Contact information:

Courtney Wheatley-Guy Ph.D.

(480) 301-6616

More information


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