A Study to Evaluate MYK-491 to Treat Patients with Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants

Overview

About this study

The purpose of this study is to establish safety and preliminary effectiveness of treatment with MYK-491 in patients with primary dilated cardiomyopathy (DCM) due to MYH7 or TTN variants .

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

- Has stable primary dilated cardiomyopathy due to either MYH7 or TTN variant

- Has adequate acoustic windows for echocardiography

- Maximum of 3 family members with same variant can be enrolled

Exclusion Criteria:

- Significant structural cardiac abnormalities including valvar dysfunction on Screening
transthoracic echo(s)

- A pathogenic variant implicated in DCM of another gene other than MYH7 or TTN

- Routinely scheduled outpatient intravenous (IV) infusions for heart failure (e.g.,
inotropes, afterload reduction, or diuretics)

- Presence of protocol specified laboratory abnormalities at Screening

- Recent acute coronary syndrome or angina pectoris (<90 days)

- Recent hospitalization for heart failure (<90 days)

Eligibility last updated6/21/22. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Naveen Pereira, M.D.

Open for enrollment

Contact information:

Susan Milbrandt C.C.R.C.

(507) 538-6105

milbrandt.susan@mayo.edu

More information

Publications

Publications are currently not available
.

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