A Study to Evaluate the Safety and Effectiveness of AB928-Based Treatment Combinations to Treat Patients with Metastatic Colorectal Cancer

Overview

About this study

The purpose of this study is to evaluate the clinical activity, safety and tolerability of etruma-based treatment combinations.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Male and female participants ≥ 18 years of age.
  • Histologically confirmed metastatic colorectal adenocarcinoma.
  • Must have at least 1 measurable lesion per RECIST v1.1. 
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. 
  • Life expectancy at least 3 months.  
  • Adequate hematologic and end-organ function. 
  • Negative HIV, Hep B and Hep C antibody testing. 
  • Agreement to remain abstinent or use contraceptive measures with female partners of  reproductive potential, and agreement to refrain from donating sperm, for 30 days after the last dose of etrumadenant, 90 days after the last dose of zim, 180 days after mFOLFOX-6 and 180 days after bev, whichever is longer.  

Inclusion Criteria for Cohort A:

  • Disease progression following not more than one prior line of treatment for mCRC that consisted of oxaliplatin or irinotecan containing chemotherapy in combination with a biologic agent.

Inclusion Criteria for Cohort B:

  • Disease progression during or following not more that two separate lines of treatment for mCRC that consisted of oxaliplatin, and irinotecan containing chemotherapy in combination with a biologic agent.

Exclusion Criteria:  

  • Previous anticancer treatment within 4 weeks prior to initiation of study treatment.
  • Prior allogeneic stem cell or solid organ transplant. 
  • Treatment with systemic immunostimulatory agents within 4 weeks prior to initiation of study treatment. 
  • Use of any live vaccines against infectious diseases within 28 days of first dose.
  • Symptomatic, untreated, or actively progressing central nervous system (CNS)  metastases.  
  • Current treatment with anti-viral therapy for HBV.
  • Structurally unstable bone lesions suggesting impending fracture. 
  • History or leptomeningeal disease.  
  • History of idiopathic pulmonary fibrosis, organizing pneumonia, drug induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis on screening chest CT scan. 
  • History of malignancy other than colorectal cancer within 2 years prior to screening, except for malignancies such as non-melanoma skin carcinoma or ductal carcinoma in situ. 
  • Active tuberculosis. 
  • Treatment with therapeutic oral or intravenous (IV) antibiotics within 2 weeks prior to initiating study treatment.
  • Severe infection within 4 weeks (28 days) prior to initiation of study treatment.
  • Significant cardiovascular disease, unstable or new onset of angina within 3 months  prior to initiation of treatment, or myocardial infarction within 6 months prior to  study treatment or unstable arrhythmi.
  • Major surgical procedures, other than for diagnosis, within 4 weeks prior to  initiation of study treatment, or anticipation of need for major surgical procedure during the study.
  • Known allergy or hypersensitivity to any of the study drugs or their excipients.
  • Inability to swallow medications.
  • Malabsorption condition that would alter the absorption of orally administered medications.  
  • Evidence of inherited bleeding diathesis or significant coagulopathy at risk of  bleeding (i.e., in the absence of therapeutic anticoagulation).
  • Prior treatment with an agent targeting the adenosine pathway.
  • Active or history of autoimmune disease or immune deficiency, including, but not  limited to, myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus  erythematosus, rheumatoid arthritis, inflammatory bowel disease, antiphospholipid  antibody syndrome, Wegener granulomatosis, Sjögren syndrome, Guillain Barré syndrome, or multiple sclerosis.  

Exclusion Criteria for Cohorts A and B:  

  • Prior treatment with immune checkpoint blockade therapies including anit-cytotoxic T lymphocyte-associated protein-4, anti PD-1, and anti-PD-L1 therapeutic antibodies.
  • Mutation in the BRAF oncogene.
  • Patients with unknown BRAF status will be required to  undergo testing at a local laboratory and provide results at screening.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Tanios Bekaii-Saab, M.D.

Contact us for the latest status

Contact information:

Cancer Center Clinical Trials Referral Office

855-776-0015

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20515342

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