Analysis of Orthobiologic Agents (OBA) for Painful Musculoskeletal Conditions and Tissue Regeneration


About this study

The objectives of this study are to determine the effect of patient factors and manufacturing procedures on OBA product characteristics, to assess the clinical outcomes of patients affected by multiple painful musculoskeletal disorders and tissue regeneration needs that are treated with guided procedures in the Mayo Clinic Pain practice, to assess genetic and epigenetic factors associated to multiple painful musculoskeletal disorders and tissue regeneration needs, to determine the effect of OBA characteristics on patient outcomes for patients treated with OBA procedures, including a reference group of patients not receiving OBAs as part of their medical care.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients undergoing standard of care PRP or BMAC injections for musculoskeletal pain conditions.
  • Age: ≥ 18.

Exclusion Criteria:  

  • Age: < 18.
  • Active cancer.
  • Other complex medical conditions determined by PI as preventing the patient for receiving orthobiologic agents (OBA) therapy.

Eligibility last updated 2/1/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Wenchun Qu, M.D., Ph.D.

Open for enrollment

Contact information:

Wenchun Qu M.D., Ph.D.

(904) 953-7246

More information


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