A Study to Evaluate Personalized Molecular Marker and Immunoprofiling to Transform Hepatocellular Carcinoma Treatment

Overview

About this study

The purpose of this study is to evaluate whether profiling aggressive tumors for molecular alterations, together with drug testing in patient-derived 3D models, can provide crucial information for the identification of specific therapeutic targets. Additionally, immunoprofiling of microcancer model systems is crucially necessary data to enable prediction of immunotherapeutic efficacy. We postulate that our innovative approach will establish much needed immune microenvironment information and facilitate the identification of specific sensitivity profiles and biomarker signatures that correlate response to targeted agents (or combinations) with particular tumor profiles.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:  

  • Adults age ≥ 18 years.
  • Biopsy or Imaging proven hepatocellular carcinoma.
  • Scheduled to undergo tumor related surgery or biopsy at Mayo Clinic.
  • Willing to complete serial blood samples.
  • Willing and able to provide signed informed consent.

Exclusion Criteria:

  • Individuals < 18 years of age.
  • Preganant individuals.
  • Tumor quantity or cell viability expected to not be sufficient for the study analyses.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Hani Babiker, M.D.

Open for enrollment

Contact information:

Jessica Schllesinger CCRP

(904) 953-3643

Schllesinger.Jessica@mayo.edu

More information

Publications

Publications are currently not available
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CLS-20509128

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