Contribution of GLP-1 Receptor


About this study

The purpose of this study is to evaluate the role of GLP1R in the response to elevated  glucagon concentrations.

The GLP-1 receptor gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal. Results from this study may help us identify therapeutic pathways to prevent or reverse type 2 diabetes mellitus.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Weight stable, healthy subjects.
  • 18-65 years of age.
  • Willing and able to provide written consent.

Exclusion Criteria:

  • Unable/willing to provide written consent.
  • History of active disease or diabetes.
  • < 18 or > 65 years of age.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Adrian Vella, M.D.

Open for enrollment

Contact information:

Amy Zipse PBT(ASCP), CLPlb(NCA)

(507) 255-0907

More information


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