APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)


About this study

Thirteen APOLLO Clinical Centers (CCs), or Networks, will prospectively enroll eligible living kidney donors and recipients of kidneys from eligible living and deceased kidney donors transplanted at all transplant programs in the continental United States including Puerto Rico. The APOLLO Scientific and Data Research Center (SDRC or Coordinating Center) will support and participate in studies determining the impact of donor and recipient APOL1 genotypes on kidney transplant outcomes in recipients of a kidney transplant from a donor with recent African ancestry, and follow African ancestry living kidney donors for changes in vital status, kidney function and proteinuria. APOLLO’s Study Chair and NIH Project Officers have broad expertise in disparities in kidney disease, transplantation, genetic factors and social components.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria for Living Donors:

  • Living kidney donors with self-reported recent African ancestry (defined as African American, Afro-Caribbean, Hispanic black or African) will be eligible for inclusion.

Exclusion Criteria for Living Donors:

  • Participants who are unable or unwilling to provide informed consent.

Inclusion Criteria for Recipients:

  • Recipients of a kidney transplant from an eligible living or deceased donor with recent African ancestry.
  • Recipients of multi-organ transplants including a kidney plus an additional organ (i.e., liver, heart, lung, pancreas, etc.) or pediatric en bloc and dual kidney transplants.

Exclusion Criteria for Recipients:

  • Participants who are unable or unwilling to provide informed consent.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Martin Mai, M.D.

Closed for enrollment

Contact information:

Joel Espinoza

(904) 953-8855


More information


Publications are currently not available

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