Aortic Valve Operative Outcomes in Marfan Patients


About this study

The purpose of this study is to evaluate and compare operative outcomes of the aortic valve-sparing (AVS) and aortic valve replacement (AVR) surgical interventions in different categories of patients with Marfan syndrome and estimate the predictors of the surgical outcomes.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Prospective Component:
    • Confirmed diagnosis of Marfan syndrome;
    • Operating surgeon's decision on the necessity of the AVR or the AVS operation at scheduled time.
  • Retrospective Component:
    • Confirmed diagnosis of Marfan syndrome;
    • Aortic valve sparing operation during the period of 1999-2003.

Exclusion Criteria:

  • Prospective Component:
    • Inability to provide the informed consent by patient or responsible relatives;
    • Inability to be available for follow-up.
  • Retrospective Component:
    • None.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Hartzell Schaff, M.D.

Closed for enrollment

Contact information:

Deborah Rolbiecki

(507) 255-5027

More information


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