A Study to Evaluate Sex and Gender in Multiple System Atrophy


About this study

The primary purpose of this study is to understand the influence of sex and gender on pathophysiologic mechanisms of neurodegeneration in Multiple System Atrophy (MSA) in order to determine sex-specific hormonal factors associated with onset of symptoms in MSA.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Diagnosis of multiple system atrophy (possible or probable) based on autonomic reflex screen.
  • Females only, age 40-80 years.

Exclusion Criteria: 

  • Clinical evidence of untreated endocrine disorder (hypothyroidism, hyperthyroidism).
  • Current use of glucocorticoid hormones (prednisone, prednisolone).

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Elizabeth Coon, M.D.

Open for enrollment

Contact information:

Tonette Gehrking CAP

(507) 284-0336


More information


Publications are currently not available

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