A Study to Compare BAL CD8+ TRM Cells and Lung Fibrosis Scores in COVID-19 Infection Survivors

Overview

About this study

The purpose of this study is to correlate BAL CD8+ TRM cells and quantitative lung fibrosis scores in survivors of moderate-to-severe COVID-19 infection.

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria - COVID-19 Cohort:

  • Patient age: 60-85 years old.
  • SARS-CoV-2 infection confirmed by PCR.
  • Need for hospitalization due to COVID-19 pneumonia.
  • Need for ≥ 2L supplemental oxygen at any point during hospitalization.

Inclusion Criteria - CONTROL Cohort:

  • Patient age: 60-85 years old.
  • No pre-existing history of interstitial lung disease or chronic lung disease, except for mild COPD with FEV1 > 80% predicted and FEV1/FVC < 0.7.
  • Absence of lung infiltrate, fever or any signs or infection.
  • Undergoing bronchoscopy for evaluation of lung nodule or adenopathy.

Exclusion Criteria - COVID-19 and CONTROL Cohorts:

  • Unable to provide consent to participate in the study.
  • Patient under guardianship or curatorship.
  • Pre-existing interstitial lung disease, pulmonary fibrosis or chronic lung disease, except for mild COPD as outlined in “inclusion criteria.”
  • Active cigarette smoking, vaping or other inhalation use (former smoker providing quit >90 days prior to admission acceptable).
  • Immunocompromised host status due to ongoing therapy with methotrexate, cellcept, azathioprine, prednisone dose > 15 mg daily, rituximab, cyclophosphamide or other biologic agents.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jie Sun, Ph.D.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Hope Marlow

(507) 538-3423

Marlow.Hope@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20503345

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