The Relationship Between Deep Venous Thrombus Characteristics and Venous Dynamics with Subsequent Thrombus Resolution and Post-thrombotic Syndrome


About this study

The purpose of this study is to complete the following aims:

Aim 1: Evaluate initial thrombus characteristics by ultrasound (US) shear wave elastography (SWE) in acute, proximal, deep venous thrombus (DVT).

Aim 2: Prospectively evaluate the role of venous hemodynamics on acute proximal DVT resolution and post-thrombotic syndrome (PTS).

Aim 3: Examine biomarkers of coagulation as predictors of acute proximal DVT resolution and PTS.

Aim 4: Expand the scope of the Mayo Clinic VTE registry to include high quality outcome data on post-thrombotic syndrome.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • All male and female adults (age ≥ 18 years old) with a first acute, proximal (popliteal and above) DVT will be recruited and for aim 1.
  • For aim 2 and 3, only patients with unilateral deep vein thrombosis (with or without pulmonary embolism) will be included.

Exclusion Criteria:

  • Individuals under 18 years of age.
  • Subjects with a history of lower extremity venous stripping or harvest or a history of any venous endovascular intervention of the lower extremities.
  • Non-ambulatory, cast immobilization of the lower extremity, lower extremity paralysis.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Damon Houghton, M.D., M.S.

Open for enrollment

Contact information:

Jane McGlinch B.S.

(507) 538-6123

More information


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Study Results Summary

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Supplemental Study Information

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