About this study

The goal of this study is to develop a database of Monozygotic (MZ) and same sex Dizygotic (DZ) twins to determine the effects of highly-discordant long-term exercise histories.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

To recruit these extremely rare potential subjects, we will use a recruitment strategy that encompasses 3 recruitment arms including: 1) social media, 2) e-mail solicitation, and 3) twin registries. As applicable, ethical standards and recruitment protocols are delineated below for each recruitment arm. Because of the inherently anonymous nature of online recruitment, all potential participants will be required to complete an online survey and scripted telephone conversation with Joyner laboratory staff as screening procedures.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Contact us for the latest status

Contact information:

Jonathon Senefeld Ph.D.

(507) 255-8380


More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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