Rapid Detection of Acute Kidney Injury (AKI) in Hospitalized Patients


About this study

The purpose of this study is to develop real-time kidney behavior monitoring and enable near-immediate (within minutes) recognition of kidney distress (versus kidney damage) in hospitalized patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adults ≥ 18 years of age.
  • Undergoing an elective procedure with a relatively high risk of perioperative AKI, including cardiothoracic surgeries, percutaneous cardiac valve procedures, and vascular surgeries.
  • Ability undergo perioperative placement of bladder catheter.

Exclusion Criteria:

  • Individuals who have absolute lack of urine production (i.e., complete anuria) arising from either end stage renal disease or severe recent AKI (possible confounding abnormal urine ammonia dynamics).
  • Individuals who utilize nephrostomy or a urostomy for urine removal.
  • Individuals with a urea cycle disorder or other inherited disorder of ammonia metabolism (possible confounding abnormal urine ammonia dynamics).
  • Individuals who may be considered vulnerable including pregnant women, prisoners, and institutionalized subjects.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Leslie Thomas, M.D.

Closed for enrollment

Contact information:

Marylaura Thomas Ph.D.

(480) 342-0161


More information


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