A Study to Evaluate a Multiplex Precision Medicine System for Early Warning of Progression Toward Shock After Trauma

Overview

About this study

The purpose of this study is to evaluate performance of already developed porcine algorithms in the human “models” of lower body negative pressure (LBNP), and to obtain human model training and validation data sets from LBNP for further refinement of the algorithms.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Subjects between 18-55 years of age.
  • Non-obese (BMI < 30).
  • Non-smokers.
  • Free of any systemic diseases including hypertension, diabetes, coronary artery disease, neurologic disease, or any other major medical co-morbidity. 
  • All inclusion/exclusion criteria will be at the discretion of the Principal Investigator. 
  • Women will be either surgically sterilized or non-pregnant as determined by a urine pregnancy test. 
    • Urine pregnancy tests will be completed within 48 hours of any study intervention. If the test is positive they will not be able to participate in the study.   

Exclusion Criteria:

  • Children less than 18 years of age because they are unable to give consent and because these studies are invasive and non-therapeutic.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20502009

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