A Study to Evaluate Skeletal Muscle Performance and Cellular Adaptations to High Hemoglobin-oxygen Affinity in Humans


About this study

The purpose of this study is to determine how oxygen binding to hemoglobin affects the acute response to single leg exercise in humans.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Male or female, age 18 years or older.
  • All races and ethnic backgrounds.
  • Non-smoking.

Exclusion Criteria:

  • Individuals under 18 years of age.
  • No significant metabolic, cardiovascular or neurologic diease and no contraindications to exercise.
  • Medications that might influence the cardiovascular or respiratory responses to exercise (e.g., beta blockers and some other antihypertensives).

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Contact us for the latest status

Contact information:

Jonathon Senefeld Ph.D.

(507) 255-8380


More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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